Crossword Clue: River meeting the Mississippi at Cairo, Illinois
Here's the answer to the River meeting the Mississippi at Cairo, Illinois crossword clue, with an explanation and where it has appeared.
Definition & answer: OHIO
The answer to "River meeting the Mississippi at Cairo, Illinois" is OHIO. Ohio is a 4-letter word made up of 3 vowels and 1 consonant, beginning with O and ending with O. In a crossword grid it occupies a 4-square slot, and each of its letters also forms part of a word crossing it — so even if the clue stumps you, the crossing entries will usually hand you enough letters to fill it in.
Origin & meaning
The Ohio River flows about 981 miles and is the largest tributary of the Mississippi by volume. It formed a historic boundary between free and slave states.
Common usage
Ohio turns up frequently in crosswords precisely because of that letter mix. Short, vowel-friendly words like OHIO are a constructor's best friend: they interlock cleanly with longer entries and help a grid come together without awkward letter clashes. When you see a 4-letter slot and already have a crossing letter or two, OHIO is often quick to confirm — especially once the O or O is in place.
Crossword trivia
Because it is only 4 letters long, OHIO appears far more often in daily mini and themed puzzles than longer, more obscure words. Regular solvers come to recognize it on sight, and it is exactly the kind of entry worth committing to memory: the more common short words you know cold, the faster your solve times become.
Stuck on this clue?
If "River meeting the Mississippi at Cairo, Illinois" has you stuck, don't force it — jump to the clues crossing this slot instead. Filling in even one or two intersecting letters usually makes OHIO obvious. That crossing-first approach is the single most useful habit for improving at crosswords, and it works on everything from the quick daily Mini to a full Sunday grid.
This clue in different puzzles
Setters vary how they clue OHIO — sometimes with a straight dictionary definition, sometimes with wordplay, a pun, or a fill-in-the-blank — but the answer itself stays the same. Learning to spot the answer behind the disguise is a core crossword skill.
Example sentences
- "I had the crossing letters, so writing OHIO into the grid took no time at all."
- "Ohio is the kind of answer that clicks the moment you spot one letter."
- "Seeing 'River meeting the Mississippi at Cairo, Illinois' in the clue list, an experienced solver pencils in OHIO almost immediately."
- "Once the O was confirmed by the crossing word, OHIO was the only entry that fit."